A list of protein degradation companies. These include PROTAC companies, Molecular Glue companies, DUB companies and many other protein degradation technologies. The target protein degradations most common technology is using ubiquitin and ligases which is portrayed in this picture.
Company Database: Targeted Protein Degradation
  • Load image into Gallery viewer, A list of protein degradation companies. These include PROTAC companies, Molecular Glue companies, DUB companies and many other protein degradation technologies. The target protein degradations most common technology is using ubiquitin and ligases which is portrayed in this picture.
  • Load image into Gallery viewer, Company Database: Targeted Protein Degradation

Company Database: Targeted Protein Degradation

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Purchase this database of 100+ companies working with targeted protein degradation

Protein degraders is an umbrella term that describes the use drugs to activate the degradation of proteins in the body. This is done by using small molecules that direct the proteins to being degraded by the proteasome. The key molecule in this interaction is ubiquitin that serves to activate the interaction between the protein and the proteasome. This is being done using several different small molecules that can link the ubiquitin recruiting protein E3 ligase and the disease causing protein. Most popular are PROTACS, that are heterobifunctional small molecules, that links disease causing proteins to an E3 ligase. Another emerging technology is molecular glues that are monofunctional small molecules that is able to link E3 ligases and proteins by binding one, and modifying their affinity towards the other, thereby activating the ubiquitin proteasome pathway.

Protein degradation cycle. E3 ligase adds ubiquitin to the protein of interest. When the protein is polyubiquinated with at least 4 ubiquitins, the protein of interest is degraded in the protesome an cleaved into peptides and free ubiquitin.

The overall target protein degradation market has been estimated to be at $3.6 billion and is only set to grow in the future. As such it is no surprise to find new protein degradation companies emerging constantly, whether it be PROTAC companies, Molecular glue companies or many other protein degrading technologies.

The list of targeted protein degrading companies in the Stargazing Bio Research Protein Degrader Database work with all the related technologies at the forefront of biotech.

Additionally, you can read more about targeted protein degradation companies, whether it be PROTAC companies, molecular glue companies among others, and the technology behind them in the blog post released by Stargazing Bio Research in relation to our targeted protein degradation company database here.